LISTERINE® IS THE MOST EXTENSIVELY TESTED MOUTHWASH
A pivotal 6-month clinical study by Sharma, et al. in 2004 demonstrated that brushing and flossing reduced whole-mouth plaque by only 9.3% compared to brushing alone. But when LISTERINE® rinse was added to brushing and flossing, whole-mouth plaque was reduced by 56.3%.15
In 2015, in the most robust collection of clinical data of its kind, one landmark meta-analysis of 29 studies based its analyses on site-specific plaque scores. This meta-analysis revealed that 36.9% of subjects using mechanical methods with Listerine mouthwash experienced at least 50% plaque-free sites after 6 months, compared to just 5.5% of patients using mechanical methods alone.16
PROVEN SAFETY AND TOLERABILITY OF LISTERINE® IN CLINICAL STUDIES
Because LISTERINE® is so effective at killing bacteria, some dental professionals may wonder if its potency could result in oral adverse events or contribute to antimicrobial resistance. As powerful as LISTERINE® is, its safety is supported by 15 6-month studies conducted over a 20-year period in 3203 subjects.17** Data indicate that oral adverse events reported in LISTERINE® groups were low (<1.0%) and generally similar to those reported in brushing-only groups. No serious adverse events were reported in these studies.
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